Optimization of Irreversible Electroporation Protocols for In-vivo Myocardial Decellularization

Optimization of Irreversible Electroporation Protocols for In-vivo Myocardial Decellularization

BACKGROUND Irreversible electroporation (IRE) is a non-thermal cell ablation approach that induces selective damage to cell membranes only. The purpose of the current study was to evaluate and optimize its use for in-vivo myocardial decellularization. METHODS Forty-two Sprague-Dawley rats were used to compare myocardial damage of seven different IRE protocols with anterior myocardial infarcti...

In Vivo Irreversible Electroporation Kidney Ablation: Experimentally Correlated Numerical Models

Irreversible electroporation (IRE) ablation uses brief electric pulses to kill a volume of tissue without damaging the structures contraindicated for surgical resection or thermal ablation, including blood vessels and ureters. IRE offers a targeted nephron-sparing approach for treating kidney tumors, but the relevant organ-specific electrical properties and cellular susceptibility to IRE electr...

Optimization and Numerical Modeling in Irreversible Electroporation Treatment Planning

Tumor Ablation with Irreversible Electroporation

We report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a newly developed non-thermal tissue ablation technique in which certain short duration electrical fields are used to permanently permeabilize the cell membrane, presumably through the formation of nanoscale def...

Historical review of irreversible electroporation in medicine

The objective of this chapter is to present a historical review of the field of irreversible electroporation (IRE) in the context of its medical applications. Although relevant scientific observations were made since the 18 th century, the electroporation phenomenon was not identified as an increase of membrane permeability until mid 20 th century. After that, multiple applications of reversibl...